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    Klinika Endokrynologii, Centrum Medyczne Kształcenia Podyplomowego, Warszawa

    Kierownik Kliniki: prof. dr hab. med. Wojciech Zgliczyński


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    Prevalence of Wine Intolerance – Results of a Survey From Mainz, Germany

    Petra Wigand, Maria Blettner, Joachim Saloga, Heinz Decker
    Institute of Molecular Biophysics of the Johannes Gutenberg University Mainz



    Wine is an ancient food product, ubiquitous across cultures all over the world. Its effects on health have been extensively studied, yet there have been only a few case reports of wine intolerance or wine allergy. We studied the prevalence of self-reported wine intolerance in the adult population of Mainz, Germany.

    Continue reading

    Nietolerancja histaminy – charakterystyka choroby i postępowanie żywieniowe

    dr nauk biologicznych Patrycja Szachta

    Instytut Mikroekologii w Poznaniu

    Artykuł ukazał się w czasopiśmie specjalistycznym o żywności i żywieniu „Food Forum” nr 3/2013

    Niepożądane reakcje na pokarm kojarzą się przede wszystkim z pojęciem alergii pokarmowej, dość niestety ostatnimi czasy nadużywanym. Częsta jest jednak sytuacja, gdy alergiczne podłoże dolegliwości zostaje wykluczone, tymczasem pacjent nadal czuje się źle po spożyciu pokarmu. Przyczyną takiego stanu rzeczy może być nietolerancja pokarmowa, częstokroć błędnie utożsamiana z alergią, z uwagi na podobieństwo objawów.

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    Diamine Oxidase rs10156191 and rs2052129 Variants Are Associated With the Risk for Migraine

    Elena García-Martín, MD, PhD; Carmen Martínez, MD, PhD; Mercedes Serrador, MD, PhD; Hortensia Alonso Navarro, MD, PhD; Pedro Ayuso, MD; Francisco Navacerrada, MD; José A. G. Agúndez MD, PhD; Félix Javier Jiménez-Jiménez, MD, PhD

    Background.—Histamine has been implicated in the pathogenesis of migraine. We investigated the possible association between functional single nucleotide polymorphisms (SNPs) in the diamine oxidase gene (DAO; chromosome 7q36.1, involved in histamine metabolism) and the risk for migraine.
    Methods.—We studied the frequency of the rs2052129, rs10156191, rs1049742, and rs1049793 genotypes and allelic variants in 197 patients with migraine and 245 healthy controls using a TaqMan-based qPCR Assay.
    Results.—The DAO SNP rs10156191, which is related to decreased DAO enzyme activity, is associated with the risk of
    developing migraine, particularly in women. The odds ratio (OR) for the defect allele positivity is 1.61 (95% confidence interval 1.31-2.37) for overall migraine patients and 2.08 (1.29-3.36) for women suffering from migraine. The association was not influenced by confounders such as the age at onset, the presence of aura, positivity of alcohol as a triggering factor, positive family history of aura, or family history of allergy. Multiple regression analyses did not confirm association with the rest of genetic factors.
    Conclusion.—Our findings, which should be framed as hypothesis generating, suggest that DAO genotypes and allelic
    variants are associated with the risk for migraine in Caucasian Spanish people, especially in women.

    Key words: migraine, genetics, histamine, diamine oxidase gene, risk factor, biomarker

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    Alergia czy nietolerancja histaminy – podobieństwo kliniczne odmiennych typów nadwrażliwości pokarmowej

    Mirosława Gałęcka
    Patrycja Szachta
    Instytut Mikroekologii w Poznaniu

    Artykuł ukazał się w czasopiśmie „Dermatologia Praktyczna” nr 1/2014

    Stosunkowo niedawno odkrytym typem nadwrażliwości pokarmowej jest nietolerancja aminy biogennej – histaminy. Histamina jest wytwarzana fizjologicznie w ludzkim organizmie oraz przyjmowana z żywnością. O nietolerancji histaminy mówimy, gdy ilość opisywanej aminy w organizmie przekroczy próg tolerancji. Wynika to najczęściej ze zmniejszenia ilości bądź aktywności enzymu rozkładającego histaminę – oksydazy diaminowej (diamine oxidase – DAO), przy jednoczesnej wysokiej zawartości histaminy spożywanej w pokarmach. Objawy nietolerancji histaminy są zróżnicowane i mogą występować z różnym nasileniem, aż do sytuacji zagrożenia życia (wstrząs anafilaktyczny). Do typowych objawów zaliczamy wodnisty katar lub zaczerwienienie i świąd skóry, przypominające reakcję alergiczną. Równie często opisywana nadwrażliwość objawia się migrenami, zaburzeniami rytmu serca, bolesnymi menstruacjami, pokrzywką oraz dolegliwościami ze strony przewodu pokarmowego (biegunka, bóle brzucha). Objawy nietolerancji histaminy u pacjenta wyzwala nie tylko spożycie pokarmów bogatych w aminę, ale również inhibitorów DAO bądź stymulatorów produkcji aminy. Są to przede wszystkim produkty przetworzone, przeznaczone do dłuższego przechowywania i dojrzewające, podsuszane wędliny, sery, ryby i owoce morza oraz wybrane owoce i warzywa. Bogatym źródłem histaminy są napoje alkoholowe, szczególnie czerwone wino. Zdiagnozowanie nietolerancji histaminy jest trudne, gdyż towarzyszące jej reakcje sugerują występowanie alergii pokarmowej. Osoba nietolerująca histaminy musi stosować się do wytycznych niskohistaminowej diety eliminacyjnej bądź przyjmować suplementy diety zawierające egzogenną oksydazę diaminową, uzupełniając tym samym niedobory enzymatyczne w organizmie.

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